Used primarily as a reagent in organic synthesis, especially in the introduction of sulfonyl groups to aromatic and heteroaromatic compounds. It serves as a key intermediate in the preparation of sulfones, which are important in pharmaceuticals and agrochemicals due to their metabolic stability and biological activity. The trans-β-styrenesulfonyl chloride reacts selectively with nucleophiles such as amines and alcohols, enabling the formation of sulfonamides and sulfonate esters—functional groups commonly found in bioactive molecules. Its conjugated structure enhances reactivity in addition and cyclization reactions, making it valuable in the construction of complex organic frameworks, including those used in medicinal chemistry and materials science.