Used as a protecting group for terminal alkynes in organic synthesis, enabling selective reactions at other functional sites without interference. Its bulky triphenylsilyl group provides steric shielding, enhancing stability during transformation steps. Commonly applied in cross-coupling reactions, such as Sonogashira coupling, where controlled deprotection allows sequential bond formation. Also utilized in the synthesis of conjugated enynes and natural products, where precise alkyne manipulation is required. The silyl group can be cleanly removed under mild conditions using fluoride ions, making it ideal for multistep syntheses.