Used in skincare products for its natural UV-absorbing properties, helping to protect the skin from sun damage. It functions as a photoprotectant by absorbing ultraviolet radiation, particularly UVB rays. Found in the outermost layer of the skin, it plays a role in the body's natural defense against sunlight.

Additionally, studies suggest urocanic acid may play a role in the skin's immune system, particularly in its cis form under UV exposure, which can modulate immune responses, such as inhibiting T-cell responses, and is linked to sun-induced immunosuppression.

In the cosmetics industry, this compound is considered for use in sunscreens or UV-protective skincare products. However, its application remains in the research and development stage due to limitations in stability and external efficacy.