Z-Ligustilide is widely used in pharmaceutical and traditional medicine applications due to its bioactive properties. It exhibits anti-inflammatory and neuroprotective effects, making it a candidate for research in treating neurological disorders such as stroke and Alzheimer’s disease. It also shows potential in cardiovascular health by promoting blood circulation and inhibiting platelet aggregation. In traditional Chinese medicine, it is valued for its role in regulating menstrual cycles and relieving menstrual pain. Additionally, Z-Ligustilide has demonstrated anti-cancer activity in preliminary studies, particularly in inhibiting the growth of certain tumor cells. Its ability to modulate multiple signaling pathways contributes to its broad therapeutic potential.