Z-Ligustilide is widely used in pharmaceutical and traditional medicine applications due to its bioactive properties. It exhibits anti-inflammatory, neuroprotective, and anti-cancer activities, making it a compound of interest in drug development. It is commonly studied for its potential in treating neurological disorders such as stroke and Alzheimer’s disease, where it helps reduce oxidative stress and neuronal damage. In cardiovascular research, Z-Ligustilide shows vasodilatory effects, supporting its role in improving blood circulation and managing hypertension. Additionally, it contributes to the efficacy of herbal formulations used in gynecological treatments, particularly for menstrual disorders and menopausal symptoms. Its ability to modulate signaling pathways involved in cell survival and apoptosis also supports its investigation in oncology, especially in combination therapies. Due to its volatility and low solubility, it is often encapsulated in delivery systems to enhance stability and bioavailability in therapeutic applications.