PD 123319 ditrifluoroacetate is primarily used in research settings as a selective antagonist for the angiotensin II type 2 (AT2) receptor. It is widely employed in pharmacological studies to investigate the role of AT2 receptors in various physiological and pathological processes. Researchers use it to explore its effects on cardiovascular regulation, renal function, and neural signaling. It is also utilized in studies focusing on tissue repair, inflammation, and fibrosis, as AT2 receptors are implicated in these processes. Additionally, PD 123319 ditrifluoroacetate helps in differentiating the functions of AT2 receptors from those of the angiotensin II type 1 (AT1) receptor, providing insights into the complex renin-angiotensin system. Its application is critical in understanding the therapeutic potential of targeting AT2 receptors in diseases such as hypertension, heart failure, and neurodegenerative disorders.