5-(5-Bromothiophen-2-yl)-1H-tetrazole
≥98%
Reagent
Code: #149540
CAS Number
211943-12-3
blur_circular Chemical Specifications
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Molecular Information
Weight
231.07 g/mol
Formula
C₅H₃BrN₄S
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Registry Numbers
MDL Number
MFCD01075734
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Physical Properties
Boiling Point
157-158 °C
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Storage & Handling
Density
1.087 g/mL at 25 °C
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and losartan. The tetrazole ring serves as a bioisostere for the carboxylic acid group, enhancing metabolic stability and improving oral bioavailability. Its brominated thiophene moiety allows for further functionalization via cross-coupling reactions, making it valuable in medicinal chemistry for building complex drug molecules. Also employed in the development of new heterocyclic compounds with potential biological activity, including antimicrobial and anti-inflammatory agents.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | White to Off-White to Light brown Solid |
| Purity (%) | 98.0-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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