4'-(Bromomethyl)-[1, 1'-biphenyl]-2-carboxylic acid
95%
Reagent
Code: #152021
CAS Number
150766-86-2
blur_circular Chemical Specifications
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Molecular Information
Weight
291.14 g/mol
Formula
C₁₄H₁₁BrO₂
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Registry Numbers
MDL Number
MFCD06208233
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Storage & Handling
Storage
2-8°C, dry
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its structure allows for the introduction of biphenyl motifs with functional handles that are essential for binding to the angiotensin receptor. The bromomethyl group serves as a reactive site for alkylation or nucleophilic substitution, enabling coupling with nitrogen-containing heterocycles in active pharmaceutical ingredients. Also employed in the preparation of specialty polymers and liquid crystals where controlled molecular architecture is required. Its carboxylic acid functionality allows for easy derivatization into esters, amides, or salts to fine-tune solubility and reactivity in multi-step organic syntheses.
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