2-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide
97%
Reagent
Code: #161820
CAS Number
27589-33-9
blur_circular Chemical Specifications
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Molecular Information
Weight
370.84 g/mol
Formula
C₁₂H₁₁ClN₆O₂S₂
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Registry Numbers
MDL Number
MFCD00867321
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Physical Properties
Boiling Point
671.1°C at 760 mmHg
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Storage & Handling
Density
1.661g/cm3
Storage
2-8°C, protected from light, stored in inert gas
description Product Description
Used in the synthesis of sartan-class antihypertensive drugs, particularly as an intermediate in the preparation of angiotensin II receptor antagonists. Its tetrazole ring mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The chloro and sulfonamide groups allow further functionalization, making it valuable in medicinal chemistry for developing potent blood pressure-lowering agents. Also employed in research for designing new heterocyclic compounds with potential cardiovascular activity.
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