2-(5-Tetrazolyl)ethanamine Hydrochloride
98%
Reagent
Code: #173774
CAS Number
33841-57-5
blur_circular Chemical Specifications
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Molecular Information
Weight
149.58 g/mol
Formula
C₃H₈ClN₅
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Registry Numbers
MDL Number
MFCD09864345
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Storage & Handling
Storage
2-8°C
description Product Description
Used in pharmaceutical synthesis as a key intermediate for angiotensin II receptor antagonists, particularly in the production of sartan-class drugs like losartan and valsartan. The tetrazole ring enhances binding affinity to the angiotensin receptor due to its ability to mimic the carboxylate group while offering improved metabolic stability and bioavailability. Also employed in the development of other bioactive molecules where the tetrazole moiety serves as a pharmacophore. Its amine functionality allows for further chemical modifications, making it valuable in medicinal chemistry for building complex drug structures.
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