(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol

97%

Reagent Code: #191208
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CAS Number 160514-13-6

science Other reagents with same CAS 160514-13-6

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 252.27 g/mol
Formula C₁₄H₁₂N₄O
badge Registry Numbers
MDL Number MFCD29920703
thermostat Physical Properties
Boiling Point 527.6±60.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.315±0.06 g/cm3(Predicted)
Storage 2-8°C, Inert Gas

description Product Description

Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.

Available Sizes & Pricing

Size Availability Unit Price Quantity
100mg
10-20 days ฿6,010.00
1g
10-20 days ฿27,510.00
(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol
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Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.
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