Rehmannioside D is primarily utilized in traditional Chinese medicine for its therapeutic properties. It is often incorporated into herbal formulations aimed at enhancing kidney function and addressing related ailments. The compound is also explored for its potential anti-inflammatory and antioxidant effects, making it a candidate for managing chronic inflammatory conditions. Additionally, Rehmannioside D is studied for its role in improving blood circulation and supporting cardiovascular health. In modern research, it is being investigated for its neuroprotective properties, which could be beneficial in treating neurodegenerative disorders. Its application extends to skincare, where it is used in products designed to reduce inflammation and promote skin healing.