Comanthosid A exhibits significant anti-inflammatory activity by inhibiting the production of pro-inflammatory mediators such as nitric oxide and cytokines in activated macrophages. It has been studied for its potential use in managing chronic inflammatory conditions, including arthritis and inflammatory bowel disease. Additionally, Comanthosid A shows moderate cytotoxic effects against certain cancer cell lines, suggesting possible application in anticancer drug development. Its natural origin and bioactivity make it a candidate for further research in immunomodulatory and oncology-related therapeutics.