Atractylenolide I is widely used in traditional Chinese medicine for its anti-inflammatory and immunomodulatory properties. It is commonly applied in the treatment of gastrointestinal disorders, such as diarrhea and indigestion, due to its ability to regulate gut function. Additionally, it is utilized in managing autoimmune diseases and allergies by modulating immune responses. Its anti-cancer potential has also been explored, as it may inhibit tumor growth and induce apoptosis in certain cancer cells. Furthermore, it is incorporated into skincare products for its anti-inflammatory and antioxidant effects, helping to soothe skin irritations and reduce signs of aging.