7-dehydrocholesterol (Pure Powder)
- Product Code: 127717
a precursor of the skin in creating Vitamin D3
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| Test Name | Specification |
|---|---|
| Appearance | White to yellow solid |
| Purity | ≥ 97.5% |
| Melting point | 148-152°C |
| Specific rotation | -126.0°~-105.0° (C=1, CHCl3) |
| Moisture | ≤ 0.5% |
| 1HNMR | Consistent with structure |
7-dehydrocholesterol is a precursor of the skin in creating Vitamin D3.
| Key benefit | What the research shows | Representative study (text citation) |
|---|---|---|
| Improves skin hydration and barrier in xerosis | Daily use of a 7-DHC + vitamin D₃ cream for 4 weeks raised corneometer hydration values, lowered transepidermal water loss, eased pruritus and was well-tolerated in elderly women with dry, itchy skin. | Yahya YF et al., “Efficiency of 7-dehydrocholesterol vitamin-D₃ complex cream for xerosis and pruritus in elderly women,” J Gen Proced Dermatol Venereol Indones 8(1), 2024. (scholarhub.ui.ac.id) |
| Raises systemic vitamin D status through the skin | A randomized pilot trial showed that an aloe-based cream delivering 5 000 IU vitamin D₃ + 7-DHC daily lifted mean serum 25-hydroxy-vitamin D from 12 ng mL⁻¹ to 38 ng mL⁻¹ after 3 months without safety issues. | Sadat-Ali M et al., “Topical Delivery of Vitamin D₃: A Randomized Controlled Pilot Study,” Int J Biomed Sci 10(1), 2014. (pmc.ncbi.nlm.nih.gov) |
| Supports keratinocyte differentiation, antimicrobial peptide expression and overall barrier homeostasis | UVB-driven conversion of epidermal 7-DHC to vitamin D₃ and its active metabolites in a human skin-equivalent model generated 1α,25-dihydroxy-vitamin D₃ that regulates cornified-envelope proteins and innate-immune peptides (LL-37, β-defensin-2). | Lehmann B et al., “UVB-induced conversion of 7-dehydrocholesterol to 1α,25-dihydroxyvitamin D₃ in an in vitro human skin equivalent,” J Invest Dermatol 117(5), 2001. (pubmed.ncbi.nlm.nih.gov) |
| Acts as an intrinsic narrow-band UVB filter while permitting controlled vitamin D synthesis | 7-DHC shows three absorption maxima at 270, 280 and 295 nm, scavenging DNA-damaging photons and plateauing after ~15 % conversion, thereby balancing photoprotection with vitamin D production. | Arnold F et al., “Metabolism of Vitamin D in Skin: Benefits for Skin-Care Applications,” Cosmetics & Toiletries 2013. (cosmeticsandtoiletries.com) |
| Contributes to anti-inflammatory and wound-healing effects via local vitamin D metabolites | Topical calcitriol (generated downstream of 7-DHC) reduces keratinocyte hyper-proliferation in plaque psoriasis and accelerates re-epithelialisation in surgical wounds. | Linus Pauling Institute, “Vitamin D and Skin Health” (review), Oregon State University Micronutrient Information Center, 2016. (lpi.oregonstate.edu) |
| Formulation caveat – pro-oxidant under UVA | Substituting membrane cholesterol with 7-DHC in keratinocytes amplified UVA-induced reactive oxygen species and PGE₂ via NADPH-oxidase and mitochondrial pathways; antioxidants are therefore recommended in 7-DHC–rich topicals. | Valencia A et al., “7-Dehydrocholesterol enhances UVA-induced oxidative stress in keratinocytes,” Free Radic Biol Med 41(11), 2006. (pubmed.ncbi.nlm.nih.gov) |
Practical formulation tips
-
Combine 7-DHC with lipid-compatible antioxidants (eg, tocopherol, silymarin) to counteract UVA-triggered ROS.
-
Encapsulate in light-protected, oxygen-controlled delivery systems (liposomes, polymeric nanocapsules) to maintain stability until application.
-
Pair with broad-spectrum UV filters that spare the 290–305 nm window, allowing photoconversion to vitamin D₃ while shielding deeper UVA.
-
Optimal skin concentration ranges in commercial creams are 0.05 – 0.2 %, balancing efficacy with oxidative safety.
How to use: Ingredients in moisturizers for sensitive skin, dry skin, premature aging skin, premature aging skin.
Mixing method: Mix the oil part in the formula. Avoid heat exceeding 40C.
Usage rate: 0.1-3%
Product characteristics: Light-colored powder
Solubility: Soluble in oil.
Storage method: Shelf life: 24 months. Please store in a refrigerator at 6 °C -8 °C. Mixed cosmetics should be stored in the refrigerator.
INCI Name : 7-dehydrocholesterol
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7-dehydrocholesterol (Pure Powder)
a precursor of the skin in creating Vitamin D3
7-dehydrocholesterol is a precursor of the skin in creating Vitamin D3.
| Key benefit | What the research shows | Representative study (text citation) |
|---|---|---|
| Improves skin hydration and barrier in xerosis | Daily use of a 7-DHC + vitamin D₃ cream for 4 weeks raised corneometer hydration values, lowered transepidermal water loss, eased pruritus and was well-tolerated in elderly women with dry, itchy skin. | Yahya YF et al., “Efficiency of 7-dehydrocholesterol vitamin-D₃ complex cream for xerosis and pruritus in elderly women,” J Gen Proced Dermatol Venereol Indones 8(1), 2024. (scholarhub.ui.ac.id) |
| Raises systemic vitamin D status through the skin | A randomized pilot trial showed that an aloe-based cream delivering 5 000 IU vitamin D₃ + 7-DHC daily lifted mean serum 25-hydroxy-vitamin D from 12 ng mL⁻¹ to 38 ng mL⁻¹ after 3 months without safety issues. | Sadat-Ali M et al., “Topical Delivery of Vitamin D₃: A Randomized Controlled Pilot Study,” Int J Biomed Sci 10(1), 2014. (pmc.ncbi.nlm.nih.gov) |
| Supports keratinocyte differentiation, antimicrobial peptide expression and overall barrier homeostasis | UVB-driven conversion of epidermal 7-DHC to vitamin D₃ and its active metabolites in a human skin-equivalent model generated 1α,25-dihydroxy-vitamin D₃ that regulates cornified-envelope proteins and innate-immune peptides (LL-37, β-defensin-2). | Lehmann B et al., “UVB-induced conversion of 7-dehydrocholesterol to 1α,25-dihydroxyvitamin D₃ in an in vitro human skin equivalent,” J Invest Dermatol 117(5), 2001. (pubmed.ncbi.nlm.nih.gov) |
| Acts as an intrinsic narrow-band UVB filter while permitting controlled vitamin D synthesis | 7-DHC shows three absorption maxima at 270, 280 and 295 nm, scavenging DNA-damaging photons and plateauing after ~15 % conversion, thereby balancing photoprotection with vitamin D production. | Arnold F et al., “Metabolism of Vitamin D in Skin: Benefits for Skin-Care Applications,” Cosmetics & Toiletries 2013. (cosmeticsandtoiletries.com) |
| Contributes to anti-inflammatory and wound-healing effects via local vitamin D metabolites | Topical calcitriol (generated downstream of 7-DHC) reduces keratinocyte hyper-proliferation in plaque psoriasis and accelerates re-epithelialisation in surgical wounds. | Linus Pauling Institute, “Vitamin D and Skin Health” (review), Oregon State University Micronutrient Information Center, 2016. (lpi.oregonstate.edu) |
| Formulation caveat – pro-oxidant under UVA | Substituting membrane cholesterol with 7-DHC in keratinocytes amplified UVA-induced reactive oxygen species and PGE₂ via NADPH-oxidase and mitochondrial pathways; antioxidants are therefore recommended in 7-DHC–rich topicals. | Valencia A et al., “7-Dehydrocholesterol enhances UVA-induced oxidative stress in keratinocytes,” Free Radic Biol Med 41(11), 2006. (pubmed.ncbi.nlm.nih.gov) |
Practical formulation tips
-
Combine 7-DHC with lipid-compatible antioxidants (eg, tocopherol, silymarin) to counteract UVA-triggered ROS.
-
Encapsulate in light-protected, oxygen-controlled delivery systems (liposomes, polymeric nanocapsules) to maintain stability until application.
-
Pair with broad-spectrum UV filters that spare the 290–305 nm window, allowing photoconversion to vitamin D₃ while shielding deeper UVA.
-
Optimal skin concentration ranges in commercial creams are 0.05 – 0.2 %, balancing efficacy with oxidative safety.
How to use: Ingredients in moisturizers for sensitive skin, dry skin, premature aging skin, premature aging skin.
Mixing method: Mix the oil part in the formula. Avoid heat exceeding 40C.
Usage rate: 0.1-3%
Product characteristics: Light-colored powder
Solubility: Soluble in oil.
Storage method: Shelf life: 24 months. Please store in a refrigerator at 6 °C -8 °C. Mixed cosmetics should be stored in the refrigerator.
INCI Name : 7-dehydrocholesterol
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