Apigenin 7-glucoside is a chamomile-derived flavone glycoside that provides superior water solubility and chemical stability compared to aglycone apigenin, making it ideal for water-phase formulations and gentle cosmetic products.

This bioactive compound demonstrates potent anti-inflammatory and antioxidant properties through multiple mechanisms. In dermatological studies, liposomal apigenin-7-O-glucoside showed dose-dependent reduction of ROS-driven dermatitis, effectively scavenging superoxide and peroxyl radicals. Clinical research with apigenin-enriched chamomile creams demonstrated significant anti-inflammatory benefits in contact dermatitis patients, with liposomal formulations showing enhanced efficacy.

While the glucoside form offers improved water solubility and formulation stability, penetration studies indicate it penetrates less deeply than aglycone forms. This characteristic makes delivery systems like liposomes particularly valuable for targeting viable epidermis. The compound also exhibits antimicrobial support with documented anticandidal activity and ROS-lowering effects, beneficial for compromised skin ecosystems.

Usage: Sensitive skin formulations, calming serums, after-sun products, anti-redness treatments, barrier-support creams, soothing toners/essences, and masks for irritated skin

How to mix:

- Dissolve in the water phase at room temperature or up to 40°C

- For enhanced penetration, incorporate into liposomal systems or use nano-carriers

- Add during the cooling phase if heat-sensitive ingredients are present

- Combine with complementary actives like apigenin or chamomile extracts for synergistic effects

Usage rate: 0.05-0.5%

Product Description: Light yellow to pale yellow crystalline powder with characteristic mild odor

Solubility: Soluble in water, glycols, and hydroalcoholic solutions; poorly soluble in oils

Storage: Store in a cool, dry place away from light. Keep container tightly closed. Stable at room temperature for 24 months when properly stored.

INCI Name: Apigenin

Well-tolerated ingredient suitable for sensitive skin formulations