3',4',5,7-Tetramethoxyflavone (TML) is a potent anti-inflammatory polymethoxyflavone that specifically targets mast cells and keratinocyte inflammatory pathways, making it ideal for sensitive, reactive, and inflamed skin conditions.

Scientific research demonstrates TML's powerful mast cell stabilization properties. It inhibits human mast cell degranulation and blocks the release of inflammatory mediators including histamine, β-hexosaminidase, TNF, and CCL2. This occurs through reduction of intracellular calcium and NF-κB activity. In keratinocytes, TML suppresses TNF-α-induced inflammatory cytokines (IL-6, IL-8/CXCL8, VEGF) via mTOR pathway inhibition, directly addressing the inflammatory cascade in conditions like atopic dermatitis, psoriasis, and chronic urticaria.

Clinical testing shows excellent tolerability. An open-label pilot study with a TML-containing lotion demonstrated no irritation in 25 highly sensitive-skin patients. In a small case series (n=8) including atopic dermatitis and psoriasis patients, lesions showed improvement after 4 weeks of twice-daily application. As part of the polymethoxyflavone (PMF) class, TML shares anti-photoaging benefits demonstrated by related compounds including enhanced collagen I production, increased hyaluronic acid, and reduced oxidative stress in UV-exposed skin.

Usage: Anti-inflammatory serums, sensitive skin lotions, post-procedure soothers, anti-itch formulations, redness-reducing treatments, mast cell-targeted skincare

How to mix:

- Pre-dissolve in ethanol or propylene glycol at 1:10 ratio before adding to formulation

- For oil-based products, dissolve directly in carrier oils at 60-70°C with stirring

- For emulsions, add to oil phase before emulsification; ensure pH 5.5-7.0 in final product

- Consider encapsulation (liposomes, NLCs) for enhanced delivery and stability

Usage rate: 0.01-0.2% (start at 0.01-0.05% for sensitive skin applications; up to 0.2% for intensive treatments)

Product Description: Light yellow to pale yellow crystalline powder with no odor. Melting point 154-156°C

Solubility: Insoluble in water; soluble in ethanol, methanol, acetone, and organic solvents; slightly soluble in oils at elevated temperature

Storage: Store in tightly closed container, protected from light and moisture. Keep at room temperature (15-25°C). Shelf life: 2 years when properly stored

INCI Name: 3',4',5,7-Tetramethoxyflavone

CAS: 855-97-0