ActiveRelease™ Quercetin
- Product Code: 253088
Water‑dispersible quercetin concentrate; 0.2–2.0% (best ~0.75%), pH 4.0–7.5; add ≤40°C.
Water‑dispersible quercetin concentrate; 0.2–2.0% (best ~0.75%), pH 4.0–7.5; add ≤40°C.
ActiveRelease™ Quercetin is a quercetin (flavonol) cosmetic active delivered in a pre‑formulated, water‑dispersible concentrate designed to improve on‑skin bioavailability for photoprotection support and sensitive/irritated skin.
Preclinical and early clinical signals suggest benefits as an adjunct to sunscreen against UV‑related oxidative stress, calming cytokine signaling, and supporting superficial wound care when used in suitable carriers.
Mechanisms include ROS scavenging and down‑regulation of NF‑κB/COX‑2, JAK2/PKCδ, and adhesion molecules;
Product Description: Quercetin‑based antioxidant/soothing active for cosmetic use. Evidence‑aligned use cases: photoprotection adjunct layered with sunscreen; comfort for irritated/AD‑prone skin; supportive role in superficial wound care. Efficacy depends strongly on delivery system (e.g., liposomes, phospholipid complexes, nano‑dispersion).
Model/System | Key Endpoints | Implication |
---|---|---|
Keratinocytes / Fibroblasts | ↓ ROS; ↓ NF‑κB/COX‑2; ↓ MMP‑1/3/9; JAK2/PKCδ modulation | Matrix preservation; anti‑photoaging |
UVA/UVB models; | ↓ UV‑induced ROS; ↓ adhesion molecules; reduced erythema | Photoprotection adjunct (with sunscreen) |
Inflammatory / AD‑like models | ↓ cytokines; improved lesion scores (preclinical) | Calming for sensitive/irritated skin (supporting) |
Wound healing (animal/early clinical) | Faster closure; ↓ inflammatory infiltrate; improved granulation | Supportive in minor wounds |
Usage: Serums, creams/lotions, after‑sun soothers, post‑procedure care; layer with SPF as antioxidant support (do not replace sunscreen).
Mixing method: Pre‑formulated, water‑dispersible concentrate; add to the water phase or post‑emulsification during cool‑down (≤40°C). Work within pH ~4.0–7.5. Avoid high heat and prolonged air exposure.
Usage rate: Typical 0.2–2.0% (best 0.5–1.0% depending on system).
Product characteristics: Transparent yellow liquid (pre‑formulated concentrate).
Solubility: Water‑dispersible concentrate (liposomal/emulsion system). Mixes directly with the water phase or at cool‑down; not a dry powder.
Storage: Store cool (15–25°C), dry, and protected from light. Close tightly after use.
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