“B5-family scope: pantothenic acid supports keratinocyte proliferation/differentiation and fibroblast KGF/procollagen markers in cell models.”
Pantethine
Cosmetics
Code: 254466
40% active Pantethine concentrate for B5-family skin-conditioning, barrier-care, sensitive-skin, scalp-care, and hair-conditioning formulas.
Pantethine is a vitamin B5-family cosmetic active supplied as a 40% active concentrate for skin-conditioning, barrier-care, sensitive-skin, scalp-care, and hair-conditioning formulas.
Pantethine is the disulfide dimer form of pantetheine and is structurally related to pantothenic-acid, panthenol, and coenzyme-A biology. In finished cosmetics it is best positioned as an advanced B5-family comfort-care active: useful where the formula concept focuses on moisturized skin feel, barrier support, reduced look of stress, and improved skin/scalp conditioning.
This grade is a clear to light-yellow viscous liquid with 40.0% active content. It is water-compatible, suited to low-temperature addition, and should be protected from heat, light, and prolonged air exposure during processing and storage.
Product Description: Pantethine can be used in leave-on facial serums, moisturizing gels, barrier-care creams, toners, masks, scalp serums, shampoos, conditioners, and hair treatments. Direct cosmetic evidence for Pantethine itself should be framed carefully, while B5-family formulation practice supports its use in products designed for dry, rough, sensitive-feeling, or environmentally stressed skin and scalp. For stronger marketing claims, confirm performance with finished-product testing.
| Formulation Target | Pantethine Role | Formulation Notes |
|---|---|---|
| Barrier-care serum/cream | B5-family skin-conditioning and comfort active | Add during cool-down; combine with humectants, ceramides, niacinamide, or panthenol when compatible. |
| Sensitive-skin products | Helps support a moisturized, comfortable skin feel | Keep fragrance and solvent load low; verify irritation profile in the finished formula. |
| Scalp and hair-care systems | Conditioning support for scalp and hair feel | Add after surfactant hydration or during cool-down to minimize heat exposure and foaming. |
Usage: Suitable for serums, creams, lotions, clear gels, toners, masks, scalp serums, shampoos, conditioners, and hair-treatment products where a water-compatible B5-family active is desired.
Mixing method:
- Add to the water phase or post-emulsification cool-down phase, preferably below 40°C.
- Maintain final formula pH around 3–7; pH 4–6 is a practical target for most leave-on skin-care systems.
- Pre-dilute with a small amount of deionized water or glycol if needed for easier weighing and uniform addition.
- Avoid prolonged heat, strong oxidizing/reducing systems, high fragrance load, and unnecessary aeration. Use light-protective, well-sealed packaging for formulas with high active positioning.
Usage rate: Use 0.5–5% of this 40% concentrate (delivers ~0.2–2.0% active). Typical: 2% concentrate delivers ~0.8% active Pantethine.
Product characteristics: Colorless to light-yellow viscous liquid with characteristic odor.
Solubility: Water-compatible; soluble in water and glycols. Add with moderate mixing until uniform.
Storage: Keep sealed, protected from light, and stored below 20°C.
- Colorless to light yellow viscous liquid; characteristic odor
- Cool (15-25C)
- Cool (15-25C)
- 24 Months from manufacturing or testing date.
- 0.50% - 5.00%
- 2.00%
- Add to water phase at final step. Maintain pH 3-7. Avoid temperature above 40C and vigorous mixing. Store refrigerated.
- Heat Tolerant
- 3.00 - 7.00
- Soluble in Water, Soluble in glycols
- Cream, Lotion, Clear Gel, Toner, Mask, Serum
“Panthenol/B5-family scope: topical dexpanthenol literature supports moisturization, barrier repair, and anti-inflammatory skin-use rationale.”
“Panthenol-family clinical scope: panthenol-containing emollient systems improved skin barrier repair and hydration in randomized studies.”
“Direct Pantethine skin-cell scope: pantethine altered cholesterol biosynthesis in cultured human skin fibroblasts.”
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