Natural Vitamin E (d-alpha tocopherol, 1490IU/g)
Natural Vitamin E (d-alpha tocopherol, 1490IU/g) – fat-soluble vitamin E concentrate from vegetable oils for dietary supplements and functional foods; typical supplemental use 100–400 IU/day with meals.
Natural Vitamin E (d-alpha tocopherol, 1490IU/g) fat-soluble vitamin E concentrate from vegetable oils used as a raw material for dietary supplements, softgels and functional foods where precise α-tocopherol activity per gram is required.
| Benefit |
Typical study dose* |
Key human findings |
High-quality sources |
| 1 Antioxidant & cell protection |
~100–400 IU/day (≈67–268 mg d-alpha tocopherol), usually in divided doses with meals |
Supports protection of polyunsaturated lipids from oxidation and helps maintain vitamin E status; outcome benefits depend on population and co-nutrients. |
PubMed |
| 2 Immune & healthy aging support |
Typically 100–200 IU/day in older adults |
Studies report modulation of immune markers and oxidative stress parameters; overall effects on clinical endpoints remain modest and context-dependent. |
PubMed |
| 3 Nutritional repletion in deficiency |
Higher individualized doses under medical supervision |
Used to correct vitamin E deficiency in fat-malabsorption or rare genetic disorders; dosing and monitoring must follow clinical guidance. |
PubMed |
*Doses refer to d-alpha tocopherol equivalents from supplements; product formulations and local regulations differ.
Mechanistic highlights
- Lipid-phase antioxidant: Scavenges peroxyl radicals in lipid membranes and lipoproteins, interrupting lipid peroxidation chains and helping protect polyunsaturated fatty acids.
- Interaction with other antioxidants: Works together with vitamin C, glutathione and carotenoids; oxidized tocopheroxyl radicals can be recycled back to the reduced form by co-antioxidants.
- Membrane and immune effects: Influences membrane fluidity, cell signalling, and selected immune responses; detailed outcomes depend on dose, baseline status and diet.
Safety & practical use
- Usual supplemental range: 100–400 IU/day for adults, taken with meals containing fat for better absorption.
- Upper-dose considerations: Very high long-term doses (≥400 IU/day) have been associated in some analyses with increased bleeding risk and possible all-cause mortality in specific populations; follow local upper-intake limits.
- Drug interactions: Use caution with anticoagulants/antiplatelet drugs and in people with vitamin K deficiency or bleeding disorders.
- Populations needing supervision: Pregnancy, breastfeeding, fat-malabsorption syndromes, liver disease and patients on chemotherapy or radiotherapy should use only under medical guidance.
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