Natural Vitamin E Acetate (d-alpha tocopherol acetate, 1360IU/g)
Natural Vitamin E Acetate (d-alpha tocopheryl acetate, 1360IU/g) – stabilized vitamin E ester for robust dietary supplement and fortified-food formulations; typically used around 100–400 IU/day at the consumer level.
Natural Vitamin E Acetate (d-alpha tocopheryl acetate, 1360IU/g) stabilized ester form of vitamin E widely used in dietary supplements, softgels and fortified foods where improved oxidative stability and processing robustness are required.
| Benefit |
Typical study dose* |
Key human findings |
High-quality sources |
| 1 Vitamin E supplementation |
~100–400 IU/day (labelled as vitamin E, often as d-alpha tocopheryl acetate) with meals |
Capsules and softgels using tocopheryl acetate maintain vitamin E status and provide antioxidant support comparable to free tocopherol at equal d-alpha IU; stability during storage is typically better. |
PubMed |
| 2 Stability in finished products |
Formulation-dependent; usually 10–400 IU per serving in supplements |
Acetate ester resists oxidation during storage and during tableting, encapsulation and coating processes better than free tocopherol, supporting more predictable labelled potency over shelf life. |
PubMed |
*IU values refer to labelled vitamin E activity as d-alpha tocopherol equivalents; regulations and formulations differ between markets.
Mechanistic highlights
- Ester pro-vitamin: Tocopheryl acetate is hydrolysed by esterases in the gut and tissues to release free d-alpha tocopherol, which then acts as the lipid-phase antioxidant.
- Improved oxidative robustness: The protected ester form is less reactive during manufacturing and storage, reducing peroxide formation and off-odors in high-fat matrices.
- Nutritional equivalence at equal IU: When converted to d-alpha tocopherol, tocopheryl acetate contributes to vitamin E status in a way that is practically similar to free tocopherol at the same labelled IU in healthy individuals.
Safety & practical use
- Usual supplemental range: 100–400 IU/day for adults, often provided as d-alpha tocopheryl acetate in capsules or softgels.
- Upper-dose considerations: As with other high-dose vitamin E preparations, long-term intakes at or above 400 IU/day should respect regional upper-intake limits and bleeding-risk considerations.
- Drug interactions: Monitor use with anticoagulant/antiplatelet medications and in people with bleeding disorders or vitamin K deficiency.
- Populations needing supervision: Pregnancy, breastfeeding, fat-malabsorption, severe liver disease, cancer therapy and other high-risk groups should be managed under medical guidance.
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