Genistein EZ™ (5% Genistein Water‑Soluble) is a water‑soluble, formulation‑ready concentrate delivering 5% w/w genistein for anti‑photoaging, visible wrinkle reduction, barrier/hydration support, and tone evening in modern leave‑on skincare.
Genistein is a soy‑derived isoflavone that preferentially modulates ERβ while providing antioxidant and anti‑inflammatory activity. When used topically, it helps protect against photoaging insults, supports collagen/elastic fiber integrity, improves hydration and barrier function, and can visibly reduce wrinkle appearance.
Evidence spans human UV pretreatment studies, randomized controlled trials using genistein‑centered topical formulas, and mechanistic work in keratinocytes and dermal fibroblasts showing ROS quenching, cytokine down‑modulation, ECM preservation, barrier‑protein support (filaggrin/AQP3), and moderation of melanogenesis.
Product Description: Water‑solubilized genistein concentrate (5% w/w) built on non‑ionic solubilization with polyol/alcohol co‑solvents for direct water‑phase dosing. Mechanistic support includes ERβ‑biased modulation in estrogen‑deficient skin; antioxidant and anti‑inflammatory effects (control of UV‑triggered signaling and cytokines); MMP/ECM preservation; barrier‑protein up‑regulation (filaggrin, AQP3); and moderation of melanogenesis.
Key supporting evidence (selected): human UV pretreatment data showing photoprotection; randomized topical trials reporting wrinkle and hydration/firmness improvements for genistein‑centered formulas in postmenopausal women; mechanistic studies in keratinocytes/fibroblasts (ROS quenching, senescence attenuation, cytokine down‑modulation); and reviews summarizing barrier/ECM benefits and pigmentation moderation.
Formulation guidance (R&D): genistein’s native water solubility is extremely low, so delivery systems matter. Microemulsions, vesicular carriers (e.g., transfersomes), and optimized polyol/surfactant matrices markedly enhance solubility and cutaneous deposition and have shown ΔL* improvements in vivo when properly engineered. Permeation may be favored around mildly acidic to neutral pH. Choose packaging that limits oxygen and ethanol loss (sealed kettles during batching; airless or foil‑laminate packs to minimize headspace and evaporation).
Usage: Leave‑on serums, gel‑creams, lotions, toners, and sun/after‑sun products aimed at photoprotection/anti‑photoaging, wrinkle/firmness, hydration/barrier support, and tone evening.
Mixing method:
- Add in the cool‑down water phase (≤40°C) with moderate stirring until uniform.
- Compatible with most non‑ionic/anionic systems; high electrolytes or strongly cationic bases may haze.
- To minimize ethanol loss, keep the vessel covered during processing and avoid prolonged heating.
- Synergizes well with niacinamide, vitamin E, and ceramides for mature/photoexposed skin.
Usage rate: 1–10% (typical ~5%).
| Concentrate % |
Delivered genistein % |
| 1% |
~0.05% |
| 3% |
~0.15% |
| 5% |
~0.25% |
| 10% |
~0.50% |
Product characteristics: Clear to slightly opalescent, pale‑yellow liquid; mild solvent odor.
Solubility: Water‑soluble via non‑ionic solubilization; miscible with glycols and alcohol; not oil‑soluble.
