11beta,13-Dihydrolactucopicrin is a sesquiterpene lactone found in medicinal plants such as chicory (Cichorium intybus), contributing to their traditional use in treating digestive and liver disorders. It is used in biological and pharmacological research for its anti-inflammatory, anti-cancer, antimicrobial, and potential anti-malarial properties. Studies show it inhibits the growth of certain tumor cells, particularly in breast and colon cancer lines, and modulates immune responses by suppressing pro-inflammatory cytokines such as TNF-α and IL-6. It also demonstrates activity against Plasmodium at the cellular level and has potential as an active ingredient for treating chronic inflammatory diseases like rheumatoid arthritis. Due to its bioactivity and low toxicity in preliminary studies, it is investigated as a natural therapeutic agent and for new drug discovery from plants.