Used as an anticoagulant during percutaneous coronary interventions (PCI), particularly in patients with heparin-induced thrombocytopenia (HIT). It directly inhibits thrombin, reducing the risk of clot formation in blood vessels during procedures like angioplasty and stent placement. Its short half-life allows for rapid onset and offset of action, enabling precise control of anticoagulation without the need for routine monitoring. Also employed in cardiac surgery and hemodialysis settings where temporary anticoagulation is required.