Medifoxamine is primarily used as an antidepressant, particularly in the treatment of depressive disorders. It functions by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, which helps modulate neurotransmitter levels in the brain, improving mood and alleviating symptoms of depression. Its application is often considered for patients who do not respond well to other antidepressants, offering an alternative therapeutic option. Additionally, it may be used to manage anxiety-related symptoms associated with depression, providing a dual benefit in some cases. Its use is typically guided by a healthcare professional to ensure proper dosing and monitoring for potential side effects.