Duloxetine is primarily used as an antidepressant and anxiolytic, effectively treating major depressive disorder and generalized anxiety disorder. It is also prescribed for managing chronic pain conditions such as diabetic peripheral neuropathy and fibromyalgia. Additionally, it helps alleviate symptoms of stress urinary incontinence by increasing muscle tone in the urethra. Its dual action on serotonin and norepinephrine reuptake makes it beneficial for both mood stabilization and pain relief.