Vofopitant (GR 205171)

98%

Reagent Code: #109909
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CAS Number 168266-90-8

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 432.44 g/mol
Formula C₂₁H₂₃F₃N₆O
inventory_2 Storage & Handling
Storage -20°C, airtight, dry

description Product Description

Vofopitant (GR 205171) is a selective neurokinin-1 (NK1) receptor antagonist primarily utilized in pharmacological research. It effectively blocks the action of substance P, a neuropeptide involved in the vomiting reflex, and has been investigated for its potential to prevent nausea and vomiting, particularly those induced by chemotherapy or post-operative conditions. In research contexts, it serves as a valuable component in antiemetic studies, often combined with other agents like corticosteroids or 5-HT3 antagonists to assess enhanced efficacy. Its evaluation is especially focused on managing acute and delayed phases of chemotherapy-induced nausea and vomiting (CINV), aiming to improve patient comfort during cancer treatment simulations. Additionally, it has been explored in preclinical and early clinical studies for other conditions where substance P plays a role, such as migraine, anxiety disorders, and depression, though these applications remain under investigation and it is not approved for clinical use.

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Size Availability Unit Price Quantity
inventory 5mg
10-20 days ฿54,855.00

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