Used primarily in the treatment and prevention of malaria, particularly in regions where resistance to other antimalarial drugs like chloroquine has developed. It is often administered in combination with other antimalarial agents, such as artesunate, to enhance efficacy and reduce the risk of drug resistance. Amodiaquine is effective against the blood stages of Plasmodium parasites, including Plasmodium falciparum, the most dangerous malaria-causing species. It is commonly used in pediatric populations in endemic areas due to its effectiveness and ease of administration in oral form. Despite its benefits, long-term or high-dose use is limited by potential liver toxicity and blood-related side effects, requiring careful monitoring during treatment.