Used as an intermediate in the synthesis of antimalarial drugs, particularly in the development of artemisinin-based combination therapies (ACTs). Its unique spirocyclic structure with a peroxide bridge enables potent activity against Plasmodium species by generating free radicals that damage parasite cells. The methyl ester group facilitates improved lipophilicity and bioavailability during drug design, making it valuable in optimizing pharmacokinetic properties of novel antimalarial agents.