Used in skincare products for its moisturizing and anti-inflammatory properties, evening primrose oil helps manage conditions like eczema, psoriasis, and acne due to its high gamma-linolenic acid (GLA) content. It supports skin barrier function and reduces dryness and irritation. It is also used for hair and scalp health, particularly for dry scalp and dandruff.

Taken orally as a dietary supplement, it is commonly used to relieve symptoms of premenstrual syndrome (PMS), including breast tenderness, mood swings, bloating, and headaches. It may also help reduce joint pain and stiffness in rheumatoid arthritis when used alongside conventional treatments. Some use it to support hormonal balance during menopause, potentially easing hot flashes and night sweats.

Additionally, it is studied for its role in improving nerve function in diabetic neuropathy and supporting cardiovascular health by helping regulate cholesterol levels and blood pressure. In the pharmaceutical industry, evening primrose oil serves as an intermediate or auxiliary active substance in medications related to hormonal systems and chronic inflammation.