Comanic acid is primarily used as an intermediate in organic synthesis, especially in the preparation of dyes, pharmaceuticals, and agrochemicals. Its structure allows for functionalization at multiple sites, making it valuable in constructing complex molecules. It is also employed in the development of specialty polymers and resins where aromatic diacids contribute to thermal stability and rigidity. In research settings, comanic acid serves as a building block for metal-organic frameworks (MOFs) due to its ability to chelate metal ions. Additionally, derivatives of comanic acid find use in the synthesis of fluorescent compounds and optical brighteners used in textiles and paper industries.