Tetrafluoroterephthalonitrile is primarily used in the synthesis of advanced polymers and high-performance materials. Its incorporation into polymer chains enhances thermal stability and chemical resistance, making it valuable for applications in extreme environments. It is also utilized in the production of specialty coatings and adhesives that require durability and resistance to harsh conditions. Additionally, it serves as a key intermediate in the development of organic electronic materials, including semiconductors and optoelectronic devices, due to its electron-withdrawing properties. Its role in creating flame-retardant materials further expands its industrial relevance.