Neopentyl benzenesulfonate is a specialty chemical used primarily as an intermediate in organic synthesis. It serves as a precursor in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and contributes to agrochemical formulations, such as pesticides and herbicides.

Due to the steric hindrance provided by the neopentyl group, it is particularly valuable in research and development laboratories for studying reaction mechanisms (e.g., substitution, elimination, and rearrangement reactions) and developing novel synthetic methodologies.