Azido-PEG8-NHBoc is widely used in bioconjugation and chemical biology for its unique properties. The azide group allows for efficient click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it a valuable tool for labeling biomolecules such as proteins, peptides, and nucleic acids. The PEG8 spacer enhances solubility and reduces steric hindrance, improving reaction efficiency in aqueous environments. The NHBoc protecting group ensures stability during synthesis and can be selectively removed to expose the amine for further functionalization. This compound is particularly useful in drug delivery systems, where it aids in the controlled release of therapeutic agents, and in the development of bioconjugates for targeted cancer therapies. Additionally, it is employed in materials science for surface modification and the creation of functionalized polymers. Its versatility makes it a key reagent in the design of advanced biomaterials and diagnostic tools.