Used in bioconjugation chemistry, particularly in the preparation of cleavable linkers for antibody-drug conjugates (ADCs) and targeted therapeutics. The azide group enables click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), allowing efficient and selective coupling to alkyne-functionalized biomolecules. The disulfide (SS) bridge provides a reducible linkage, which can be cleaved under intracellular reducing conditions, facilitating controlled release of payloads such as drugs or probes. This makes it valuable in drug delivery systems where stability in circulation and intracellular activation are required. Also employed in proteomics and chemical biology for labeling and isolating biomolecules.