This compound, Nutlin-C1-amido-PEG4-C2-N3, is a modified derivative of Nutlin-3, a potent inhibitor of the MDM2-p53 protein-protein interaction, which plays a key role in cancer suppression and cellular apoptosis. It is widely utilized in biochemical and medicinal chemistry research to study protein interactions, cell cycle regulation, and tumor suppressor pathways. The amido-PEG4 linker enhances aqueous solubility and pharmacokinetic properties, while the C2-azide terminus enables precise bioconjugation through copper-free click chemistry. This makes it an essential building block for developing PROTACs (Proteolysis Targeting Chimeras) that induce targeted degradation of MDM2 or other E3 ligases, advancing cancer therapeutics. Additionally, it supports the synthesis of imaging probes, diagnostic tools, and targeted drug delivery systems to visualize and modulate molecular processes in cells.