Tetrabutylammonium azide is primarily used in organic synthesis as a reagent for the introduction of azide groups into various molecules. It is particularly valuable in click chemistry, where it facilitates the formation of triazole compounds through azide-alkyne cycloaddition reactions. This chemical is also employed in the preparation of azido derivatives, which are intermediates in the synthesis of pharmaceuticals, agrochemicals, and polymers. Additionally, it serves as a source of azide ions in nucleophilic substitution reactions, enabling the creation of complex organic structures. Its role in the development of bioactive compounds and materials science highlights its versatility in advanced chemical research and industrial applications.