Azido-PEG8-hydrazide is widely used in bioconjugation and chemical biology due to its reactive azide and hydrazide groups. The azide group allows for efficient click chemistry reactions, particularly with alkynes, enabling the attachment of molecules in a highly specific manner. This makes it valuable for labeling proteins, peptides, and other biomolecules in research and diagnostics. The hydrazide group facilitates conjugation with carbonyl-containing compounds, such as aldehydes and ketones, which is useful in modifying glycoproteins or creating stable hydrazone linkages. Its polyethylene glycol (PEG) spacer enhances solubility and reduces steric hindrance, improving the efficiency of conjugation processes. This compound is particularly useful in drug delivery systems, where it helps in creating targeted and stable conjugates, as well as in the development of biosensors and imaging probes.