Piperonaldoxime is primarily utilized in organic synthesis as a versatile intermediate. It plays a significant role in the production of various pharmaceuticals, particularly in the synthesis of compounds with potential therapeutic properties. Additionally, it is employed in the development of agrochemicals, contributing to the creation of pesticides and herbicides. Its application extends to the field of perfumery, where it is used to synthesize aromatic compounds. Piperonaldoxime also finds use in research laboratories for studying chemical reactions and developing new synthetic pathways.