Used in medicinal chemistry as a key scaffold in the development of protease inhibitors, particularly in antiviral and anticancer agents. The boron-containing structure enables reversible interactions with biological targets, enhancing binding selectivity. Commonly employed in structure-based drug design due to its metabolic stability and ability to form hydrogen bonds. Also utilized in PET imaging probes, where the trifluoromethyl group aids in improving lipophilicity and bioavailability.