Nebivolol is primarily used in the treatment of high blood pressure (hypertension). It helps to relax blood vessels, allowing blood to flow more easily and reducing the workload on the heart. This makes it effective in managing hypertension and lowering the risk of heart-related complications such as strokes or heart attacks.

Additionally, Nebivolol is prescribed for chronic heart failure. It improves heart function by reducing the heart rate and decreasing the force of heart contractions, which helps the heart pump blood more efficiently. This can alleviate symptoms like shortness of breath and fatigue, improving the quality of life for patients with heart failure.

Its unique mechanism of action, which includes beta-blockade and nitric oxide-mediated vasodilation, makes it a preferred choice for patients who may not tolerate other beta-blockers well. It is often used in combination with other medications to achieve optimal blood pressure control or heart failure management.