Mal-amide-PEG2-oxyamine is widely used in bioconjugation and chemical biology for linking molecules, particularly in the modification of proteins, peptides, and other biomolecules. Its amide group allows for stable covalent bonding with amine-containing compounds, while the oxyamine moiety enables efficient conjugation with aldehydes or ketones, making it valuable for site-specific labeling. The PEG2 spacer enhances solubility and reduces steric hindrance, improving the efficiency of reactions. This compound is commonly employed in the development of antibody-drug conjugates, bioconjugate probes, and functionalized nanoparticles for targeted drug delivery, imaging, and diagnostic applications. Its versatility also supports research in protein engineering and the study of biomolecular interactions.