12(R)-HETE plays a significant role in various biological processes, particularly in inflammation and cellular signaling. It is involved in the regulation of immune responses and has been studied for its impact on conditions like asthma and other inflammatory diseases. In cancer research, 12(R)-HETE is examined for its role in tumor progression and angiogenesis, as it can influence the growth and spread of cancer cells. Additionally, it is implicated in the modulation of vascular functions, affecting blood flow and vascular permeability. Its role in the nervous system is also under investigation, particularly in neuroinflammation and pain signaling pathways.