MPG (Membrane Penetrating Peptide) has significant applications in HIV-related research and therapy. It is primarily used as a delivery vehicle for therapeutic molecules, such as nucleic acids, proteins, and drugs, into cells. Due to its ability to efficiently cross cell membranes, MPG enhances the intracellular delivery of antiretroviral drugs, which is crucial for targeting HIV reservoirs in the body. It has been explored in the development of gene therapy strategies to inhibit viral replication by delivering siRNA or antisense oligonucleotides directly into infected cells. Additionally, MPG-based delivery systems are being investigated for improving the efficacy of HIV vaccines by enhancing antigen presentation and immune responses. Its role in overcoming biological barriers makes it a promising tool in the fight against HIV and other viral infections.