Cyclo(-L-Leu-L-Phe) is a cyclic dipeptide that has attracted interest due to its biological activity and potential therapeutic applications. It exhibits antimicrobial properties, showing inhibitory effects against certain Gram-positive bacteria, making it a candidate for development in anti-infective agents. Additionally, it has demonstrated cytotoxic activity against select cancer cell lines, suggesting a role in anticancer research. Its stable cyclic structure also makes it a useful scaffold in drug design, particularly for mimicking peptide conformations in enzyme inhibition or receptor modulation. It is studied in the context of natural product chemistry and microbial metabolites, often as part of broader efforts to discover bioactive compounds from microbial sources.