RFRP-3, also known as RFamide-related peptide-3, plays a significant role in regulating reproductive functions. It acts as an inhibitor of gonadotropin-releasing hormone (GnRH) secretion, which in turn influences the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This makes it a potential target for managing reproductive disorders, such as infertility or conditions involving irregular hormonal cycles. Additionally, RFRP-3 has been studied for its role in stress responses and its potential impact on mood and behavior, suggesting applications in neuroendocrine research and therapeutic interventions for stress-related disorders. Its ability to modulate reproductive and stress pathways highlights its importance in both clinical and research settings.