Diethylstilbestrol has been historically used in medical applications, primarily as a synthetic estrogen to treat various conditions. It was prescribed to prevent miscarriages and manage menopausal symptoms, though its use for these purposes has been discontinued due to associated health risks. In veterinary medicine, it has been employed to promote growth in livestock and manage reproductive issues in animals. Additionally, it has been utilized in certain hormone therapies and research studies to understand estrogen-related mechanisms. However, its use is now heavily restricted due to its carcinogenic potential and adverse effects on human health.