Used in research to study stress responses and adrenal function, corticosterone plays a key role in understanding glucocorticoid signaling in the brain and body. It is applied in neuroscience to investigate anxiety, memory, and depression in animal models. Commonly used in rodent studies, it helps simulate chronic stress conditions and examine the effects of elevated stress hormones on behavior, metabolism, and immune function. Also utilized in endocrinology to explore hormone regulation and feedback mechanisms in the hypothalamic-pituitary-adrenal (HPA) axis.