Used in research to study stress responses and adrenal function, corticosterone plays a key role in understanding glucocorticoid hormone effects on metabolism, immune activity, and behavior. It is applied in neuroscience to investigate mood disorders, anxiety, and depression in animal models. Also utilized in endocrinology studies to examine hormone regulation and feedback mechanisms in the hypothalamic-pituitary-adrenal (HPA) axis. In immunology, it helps assess the impact of stress hormones on inflammation and immune suppression. Additionally, corticosterone is used in cell culture and in vivo experiments to mimic physiological stress conditions.