Used in bone metabolism studies to quantify β-isomerized C-terminal telopeptide of type I collagen, a biomarker for bone resorption. Enables assessment of osteoclast activity in research settings, particularly in osteoporosis, metabolic bone diseases, and drug development. Commonly applied in preclinical and clinical research to monitor the effectiveness of antiresorptive therapies such as bisphosphonates and denosumab. Provides a sensitive and specific measurement of bone turnover in serum and plasma samples, supporting longitudinal studies on bone health and disease progression.